Heterochromatin and gene regulation in Drosophila
نویسندگان
چکیده
منابع مشابه
Developmental regulation of heterochromatin-mediated gene silencing in Drosophila.
The roles of differentiation, mitotic activity and intrinsic promoter strength in the maintenance of heterochromatic silencing were investigated during development using an inducible lacZ gene as an in vivo probe. Heterochromatic silencing is initiated at the onset of gastrulation, approximately 1 hour after heterochromatin is first visible cytologically. A high degree of silencing is maintaine...
متن کاملDifferential gene silencing by trans-heterochromatin in Drosophila melanogaster.
The brown(Dominant) (bw(D)) allele contains a large insertion of heterochromatin leading to the trans-inactivation of the wild-type allele in bw(D)/bw(+) heterozygous flies. This silencing is correlated with the localization of bw(+) to a region of the interphase nucleus containing centric heterochromatin. We have used a series of transgene constructs inserted in the vicinity of the bw locus to...
متن کاملHeterochromatin of Drosophila Melanogaster
We examined the behavior of an autosomal recessive maternal-effect mutation, abnormal-oocyte (abo), that is located in the euchromatin of the left arm of chromosome 2. When homozygous in females, abo results in a marked reduction in the probability that an egg produced by a mutant mother will develop into an adult. However, this probability is increased if the fertilizing sperm delivers to the ...
متن کاملOn the Evolution of Yeti, a Drosophila melanogaster Heterochromatin Gene
Constitutive heterochromatin is a ubiquitous and still unveiled component of eukaryotic genomes, within which it comprises large portions. Although constitutive heterochromatin is generally considered to be transcriptionally silent, it contains a significant variety of sequences that are expressed, among which about 300 single-copy coding genes have been identified by genetic and genomic analys...
متن کاملpiRNA Production Requires Heterochromatin Formation in Drosophila
Protecting the genome from transposable element (TE) mobilization is critical for germline development. In Drosophila, Piwi proteins and their bound small RNAs (piRNAs) provide a potent defense against TE activity. TE targeting piRNAs are processed from TE-dense heterochromatic loci termed piRNA clusters. Although piRNA biogenesis from cluster precursors is beginning to be understood, little is...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 1996
ISSN: 0959-437X
DOI: 10.1016/s0959-437x(96)80050-5